RIFM President Focuses on Science, Society and Assessment

« The Research Institute for Fragrance Materials’ (RIFM) new president, James Romine, is interested in how science plays out in a dynamically changing world.

“Even though RIFM is strictly a science-based organization, we don’t live in a vacuum. Society around us is an important component and constituent, so I’m always interested in how the science plays out in the broader context of society,” Romine tells P&F.

RIFM aims to support the fragrance industry, in particular its member companies, while continuing its work on safety assessments amid an environment of regulatory and ingredient disclosure pressures. There are also untapped opportunities to possibly grow RIFM’s membership in other segments, according to Romine.

“Our primary goal is to continue to provide safety assessments for fragrance materials that are used in our industry,” Romine says.

He continues, “But another important goal is to support the science of toxicology and risk-assessment, which is really developing quickly around us, necessitating changes in how we work.”

For instance, he cited developing methodologies to supply the kinds of answers needed for research and to address ethical concerns, like minimizing animal testing.

Romine says, “Computational toxicology, in silico, other computational models—or even alternative assays that get us high-quality answers—is where RIFM is investing its resources.”

As far as animal testing is concerned, he says, “RIFM started moving to non-animal testing more than 10 years ago [by] participating in [Johns Hopkins Center for Alternatives to Animal Testing] CAAT and the 3Rs program. Soon after, we began correlating our non-animal testing results with our in vivo testing. It is very important for RIFM to meet the needs of industry and our stakeholders in other organizations and society to assure that fragranced products are safe, while performing our safety evaluations in an ethical and responsible way.”

Romine, who took the helm after being named by the board in July, has a Ph.D. in chemistry from the University of Michigan and spent most of his career at DuPont where he held 10 positions in different business sectors over his 35-year tenure at the company. In his last position, he was responsible for product stewardship and product regulatory compliance for the company’s global businesses, and also helped shape DuPont’s public perception and acceptance with a wide range of stakeholders. He began his tenure in this area just before REACH went into force in the EU.  « 


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IFEAT/ RIFM First Results of Essential Oil Safety Testing Complete

« The International Federation of Essential Oils and Aroma Trades (IFEAT) is working with the Research Institute for Fragrance Materials (RIFM) on evaluation the safety of essential oils, using BlueScreen HC and other technologies and has completed its first round of testing results.

According to an International Trade Centre Report, the program focuses on testing the complete oil, in contract to most previous testing which looked at individual constituents and isolates as sources of toxicity.

It said the program’s intention is to assess the potential carcinogenic, mutagenic and reproductive toxicity of around 200 naturals chosen on the basis of their relative production volume, REACH compliance and other industry-relevant criteria.

All the oils tested negative for evidence of genotoxicity in each of the the assays, according to the report.

« The assessment for each oil involves a battery of tests designed to determine whether the material can cause mutations or cellular toxicity in a living system. If an essential oil produces a positive result in any test, it will be evaluated in greater detail, » the report said.

The report said the initial battery of tests were:

BlueScreen HC, conducted by Getronix Laboratories, is an assay composed of mammalian cells that measures the genotoxicity and cytotoxicity of a mixture or compound;

Bacterial Reverse Mutation Assay (OECD 471), the Ames Test, which determines the incidence of mutations in a bacterial cell culture that has been exposed to an essential oil or other material; and

In vitro Micronucleus Assay (OECD 487) that evaluates the cytogenecity of the essential oil in in vitro human peripheral blood tissue. The test provides information on whether a material interferes with cell reproduction during the process of cell division.

The first five essential oils to be tested, according to the Report, were:

Eucalyptus citriodora oil

• Fir needle oil (Siberian)

• Geranium oil (African)

• Petitgrain oil (Paraguay)

• Rose oil (Bulgarian)  « 


IFEAT World, September 2015, page 3 : http://www.ifeat.org/wp-content/uploads/2015/09/Ifeat-World-Sept-15-web_..pdf


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5 New RIFM Safety Assessments

5 new RIFM Safety Assessments are now available at the Fragrance Material Safety Assessment Center:

2-methyl-3-buten-2-ol; CAS Number 115-18-4



Benzyl acetate; CAS Number 140-11-4


Isophytol; CAS Number 505-32-8



(Z)-2-penten-1-ol; CAS Number 1576-95-0



(2E,6Z)-Nona-2,6-dien- 1-ol; CAS Number 28069-72-9




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RIFM’s 49th Annual Meeting – Innovation in the Fragrance Industry

Join Us For RIFM’s 49th Annual Meeting

Thursday, November 5, 2015 -The Estate at Florentine Gardens NJ 07675


Meeting Agenda

Business Meeting 3:30 pm
Expert Panel Update
Dr. Daniel C. Liebler, Professor, Biochemistry, Pharmacology & Biomedical Informatics
Vanderbilt University School of Medicine
Challenges of inference in chemical safety evaluation

Cocktail and Networking Reception 5:00 pm
Informative Demos on Non-Animal models and the latest computative safety assessment tools
Poster presentations on RIFM programs

Dinner 6:30 pm
Dinner Presentation Panel Discussion – Innovation in the Fragrance Industry

Janis Gaudelli, Sr. Manager, Social Media & Trend Insights, Takasago

Karen Dubin, co-founder of Sniffapalooza
Victoria Frolova, Owner, Bois de Jasmin Blog
Dr. Jenny Tillotson, Creator of eScents, Institute of Biotechnology, University of Cambridge


Site: http://www.rifm.org/events-detail.php?id=151#.VgBwepdF3W5

Cet article n’engage que son auteur/ This article is the sole responsibility of the author