» The cosmetics and skin care industry is constantly developing new products and technologies that aim to slow down the skin aging process. Epigenetic processes play an important role in skin aging. Several new cosmetic products target epigenetic mechanisms and have shown promising results as novel cosmeceuticals.
Epigenetics describes the physiological reprogramming that occurs in the cell without changes in the DNA sequence. The main epigenetic tools used by the cell are:
- DNA methylation
- histone modifications
- histone variants
- chromatin remodeling nanomachines, and
- the regulatory activity of microRNAs (miRNAs).
The combinative use of these tools regulates the accessibility of the DNA to outside factors in the nucleus, which affects vital cellular processes including transcription and DNA repair. Although the study of epigenetics in clinical medicine is relatively new, the applications to dermatology are profound—with mechanisms and future therapeutic modalities being examined in melanoma, cutaneous T-cell lymphoma, psoriasis and aging. The cosmetic industry has taken serious interest and begun to develop new anti-aging products that target epigenetic processes. (…) »
These products use a Himalayan red rice active ingredient, which works by decreasing DNA methylation levels on gene promoter regions.
Article in Cosmetics & Toiletries by Nikifor K. Konstantinov (University of New Mexico School of Medicine, Albuquerque, New Mexico), Constance J. Ulff-Møller M.D. (Rigshospitalet, Copenhagen University Hospital, Denmark), Stefan Dimitrov, Ph.D. (Institut Albert Bonniot, Grenoble Cedex 9, France), Howard I. Maibach, M.D. (University of California, San Francisco, California, USA)