« FDA- Approved Drugs Boost Hair Regrowth In Mice »- Chemical & Engineering News

« Hair Loss: JAK-STAT inhibitors already being used to treat autoimmune disorders prompt hair follicles to reboot their growth cycles.

Although the idea of going bald typically conjures images of aging men, hair loss affects people of all genders and ages: Hair can fall out prematurely because of genetic predisposition, stress, drug side effects, or autoimmune disorders. A recent test of two FDA-approved drugs—ruxolitinib and tofacitinib—now suggests that a general treatment for all these hair loss conditions might be on the way (Sci. Adv. 2015, DOI: 10.1126/sciadv.1500973).

A team of researchers at Columbia University had observed that these drugs—approved for the treatment of myelofibrosis and rheumatoid arthritis, respectively—promoted hair growth when fed to mice but also impaired the animals’ immune systems. So the scientists were curious whether the compounds might work better when rubbed onto the rodents’ skin rather than when administered orally. (…) »

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« Hairy Situation- When treated topically on the right sides of their shaved backs with ruxolitinib (center) and tofacitinib (right), mice robustly regrew hair compared with a control (left). »

Article published on 26.10.2015, by Judith Lavelle, on Site Chemical & Engineering News

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Publication : http://advances.sciencemag.org/content/1/9/e1500973