« A Macrocyclic ‘Hole’ That Fits Round and Square Molecular ‘Pegs’ »- RSC Publishing

« Researchers from the South University of Science and Technology of China have developed a structurally dynamic macrocycle, which is able to modulate the dimensions of its internal cavity and show binding affinities for molecular guests of a range of shapes and sizes.

As children, we learn very early on about the concept of shape and size complementarity. No matter how many times you try, the square peg doesn’t fit in the round hole, and that second (or third!) piece of cake just wasn’t a good idea. This same concept also extends to supramolecular interactions, especially when we consider the arena of host–guest chemistry.

Generally speaking, the conformation of a macrocyclic host is relatively rigid, which means that the scope of host molecules it can encase is also somewhat limited. Whilst this feature of host–guest chemistry and molecular recognition is the basis for a range of catalytic events and the template-directed synthesis of mechanically interlocked molecules, it would be advantageous in expanding the scope of this field if a macrocycle existed that could happily host a wide range of guest molecules. (…) »


Oxatub[4]arene: A smart macrocyclic receptor with multiple interconvertible cavities
Fei Jia, Zhenfeng He, Liu-Pan Yang, Zhi-Sheng Pan, Min Yi, Ren-Wang Jiang and Wei Jiang
Chem. Sci., 2015, Advance Article.
DOI: 10.1039/C5SC03251B


Article d’ Anthea Blackburn du 26.10.2015, Site Royal Society Of Chemistry Publishing