« Six new guidelines and 11 updates to toxicity tests:
The OECD has published 6 new and 11 updated chemical test guidelines (TGs) on its website.
The new guidelines are:
TG 240: Medaka extended one generation reproduction test (MEOGRT);
TG 241: larval amphibian growth and development assay (Lagda);
TG 490: in vitro mammalian cell gene mutation test, using the thymidine kinase gene;
TG 491: short-time exposure in vitro test method for identifying i) chemicals inducing serious eye damage and ii) chemicals not requiring classification for eye irritation or serious eye damage;
TG 492: reconstructed human cornea-like epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage; and
TG 493: performance-based test guideline for human recombinant oestrogen receptor (hrER) in vitro assay to detect chemicals with ER-binding affinity.
The updated guidelines are:
TG 404: acute dermal irritation/corrosion;
TG 421: reproduction/developmental toxicity screening test;
TG 422: combined repeated dose toxicity study with the reproduction/developmental toxicity screening test;
TG 430: in vitro skin corrosion: transcutaneous electrical resistance test method (TER);
TG 431: in vitro skin corrosion: reconstructed human epidermis (RHE) test method;
TG 435: in vitro membrane barrier test method for skin corrosion;
TG 439: in vitro skin irritation: reconstructed human epidermis test method;
TG 455: draft performance-based test guideline for stably transfected transactivation in vitro assays to detect oestrogen-receptor agonists and antagonists;
TG 476: in vitro mammalian cell gene mutation tests, using the Hprt and xprt genes;
TG 478: rodent dominant lethal test; and
TG 483: mammalian spermatogonial chromosomal aberration test.
The OECD is also calling for laboratories to submit data for a feasibility project on improving study TG 414 on prenatal development toxicity.
The aim is to examine the feasibility of inclusion of sensitive endpoints for the detection of chemicals with endocrine disrupting (ED) properties in TG 414. The project was launched by Denmark in April, and the data is required before 25 September. »
OECD webpage : http://www.oecd.org/env/ehs/newlypublishedsetoftestguidelines.htm
Call for data to enhance Test Guideline 414 : http://www.oecd.org/env/ehs/call-for-data-to-enhance-test-guideline-414-with-endocrine-disrupter-relevant-endpoints.htm
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